About 90 % of breast carcinomas arise from tumor proliferation of the ductal epithelium. Basal and squamous cell skin cancer early detection. It often arises within solar actinic keratosis or within squamous cell carcinoma in situ. Squamouscell carcinoma of the lung is strongly associated with tobacco. Eccrine porocarcinoma is a rare cutaneous malignancy that arises from the intraepidermal ductal portion of the eccrine sweat gland acrosyringium. Squamoid eccrine ductal carcinoma sedc is an exceedingly rare tumor that shows both squamous and adnexal ductal differentiation. Squamoid eccrine ductal carcinoma is a poorly documented skin adnexal carcinoma showing squamous and duct differentiation. Squamoid eccrine ductal carcinoma, histopathology 10. We report a case of this unusual tumor occurring on the occiput of a 53yearold man.
Initial histology of both lesions revealed carcinoma with squamous and ductal differentiation that extended from. Squamoid eccrine ductal carcinoma sedc is an uncommon cutaneous adnexal malignancy tha. Squamoid eccrine ductal carcinoma sedc is a subtype of malignant tumours of skin appendices, showing eccrine and apocrine differentiation. Related to the recent report on squamoid eccrine ductal carcinomas by wong et al. The immunohistochemistry supported an adnexal tumor over a squamous cell carcinoma. In our case, we present a 46 yearold female with a recurring exophytic tumor on the right lower extremity, without local extension. The annual incidence of cscc is from 200,000 to 300,000 per year and constitute 20% of nonmelanoma skin cancers 1.
Squamous cell carcinoma of the breast tends to grow rapidly and is resistant to chemotherapy 2. In skin, tumor cells destroy the basement membrane and form sheets or compact masses which invade the subjacent connective tissue dermis. Read squamoid eccrine ductal carcinoma, histopathology on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Clear cell squamous cell carcinoma of the cervix is a glycogenrich cancer with intercellular bridge formation characteristic of squamous. Squamoid eccrine ductal carcinoma should be considered in the differential diagnosis of cutaneous adnexal neoplasms showing squamoid and ductal features of. Histopathology skinsquamous cell carcinoma youtube. An unusual morphological presentation of cutaneous squamous. Histology of the excised lesion showed an ulcerated highly infiltrative tumor composed of strands and islands of squamous cells, showing. It is regarded to be of lowgrade malignant potential, but limited followup information is available. Three out of the six cases with carcinoma of nst showed small foci of specialized differentiation. Squamous differentiation in eccrine porocarcinoma epc is an unusual phenomenon that has rarely been reported in the literature. New ish entities endocrine mucinproducing sweat gland carcinoma primary cutaneous cribriform carcinoma squamoid eccrine ductal carcinoma. Almost half of patients are misdiagnosed as squamous cell carcinoma by the incisional biopsy. After 5 days, an erythematous, blanching, papular, crusted eruption.
The term in situ refers to those tumors in which the tumor cells did not penetrate the basement membrane into the surrounding tissue. Eccrine ductal carcinoma fig 17a resembles breast ductal carcinomas, with different growth patterns possibly seen in isolation or in combination, including solid, papillary, tubular and cribriform. It is the second most prevalent type of lung cancer after lung adenocarcinoma and it originates in the bronchi. Squamous cell carcinoma is a malignant epithelial tumor which originates in epidermis, squamous mucosa or areas of squamous metaplasia. Eccrine carcinoma an overview sciencedirect topics. Invasive ductal carcinoma of the breast atlas of pathology.
Morphealike basal cell carcinoma lacks the configuration of glandular lumen or specific tumor zones. Pdf squamoid eccrine ductal carcinoma is an eccrine carcinoma subtype, and only. Department of pathology, pusan paik hospital, inje university college of medicine, busan, korea. Eccrine carcinoma syringoid carcinoma eccrine carcinoma syringoid carcinoma, ductal eccrine carcinoma is a rare tumor which usually presents as a slowly growing infiltrating plaque on the scalp, 1458 or as a plaque or nodule on the extremities or trunk. We report the thirteenth case of squamoid eccrine ductal carcinoma. Ductal eccrine carcinoma with squamous differentiation. Sections of eccrine carcinoma show a tumour composed of basaloid cells infiltrating the dermis figure 1. After excision, histopathology revealed positive margins. The incisional biopsy diagnosed squamoid eccrine ductal carcinoma.
Esophageal cancer may be due to either esophageal squamous cell carcinoma escc or adenocarcinoma eac. Squamoid eccrine ductal carcinoma semantic scholar. Initial histology of both lesions revealed carcinoma with squamous and ductal differentiation extending from the undersurface of the epidermis, favoring a diagnosis of sedc figure 2. It is also associated with frequent development of cystic lesions 3, showing aggressive. Squamoid eccrine ductal carcinoma sedc is a rare primary cutaneous tumor that exhibits both squamous and adnexal ductal differentiation. On examination, the breast mass was large, measuring approximately 8 cm and was tender to palpation. Squamoid eccrine ductal carcinoma ductal eccrine carcinoma with squamous differentiation is an exceedingly rare tumor that shows eccrine ductal differentiation combined with a squamoid component characterized by prominent squamous proliferation with atypia, keratinous cyst formation, and squamous eddies fig. A 31yearold hispanic man presented in the pancytopenic phase of acute myelocytic leukemia and was treated with the chemotherapeutic agents mitoxantrone and cytarabine. Squamoid eccrine ductal carcinoma of the scalp journal of. Squamouscell carcinoma scc of the lung is a histologic type of nonsmallcell lung carcinoma nsclc. The gross description of these lesions has been of rated area to a polypoid broad based mass. Ductal carcinoma in situ is a unicentric proliferation, typically involving one duct system.
The low power view of this tumour shows an epithelial tumour extending from the epidermis to the deep dermis. Pdf squamoid eccrine ductal carcinoma researchgate. The tumour was located on the right knee and had been present for. Eccrine carcinoma is an extremely rare malignancy of the skin with few well documented cases reported in the literature. Squamoid eccrine ductal carcinoma sedc is a rare skin tumor characterized by atypical squamous epithelial prolif eration and eccrine ductal differentiation. Differentiation is mandated betwixt microcystic adnexal carcinoma and fibrosing basal cell carcinoma with follicular differentiation. The overall features were of a squamoid eccrine ductal carcinoma sedc. Eccrine porocarcinoma is sufficiently distinctive in terms of a precursor lesion of poroma and its predilection for distal extremities makes its separation from sedc reasonable. Squamoid eccrine ductal carcinoma mdedge dermatology. Among the multiple subtypes of eccrine carcinomas, squamoid eccrine ductal carcinoma sedc is characterized by prominent squamoid differentiation, resembling squamous cell carcinoma scc. A 29yearold woman with no significant medical history presented with a rapidly growing and painful left breast mass.
Squamoid eccrine ductal carcinoma the dermatologist. Sccs tend to occur closer to the mouth, while adenocarcinomas occur closer to the stomach. Eccrine carcinoma diagnostic pathology biomed central. Squamous cell carcinoma scc is common form of keratinocytic skin cancer, usually related to exposure to ultraviolet radiation from sunlight. Squamoid eccrine ductal carcinoma of the ear helix yim 2019. At the time of initial presentation, the patient also had a 6mm pink papule on the right chest of several months duration that was consistent with a welldifferentiated sebaceous carcinoma on histology. It is a rare tumor and its histopathological diagnosis is difficult. Histopathologically, the tumor component is composed of an admixture or separate areas of scc and. Webmd explains the symptoms of different types of carcinomas, including basal cell, squamous cell, renal cell, and invasive ductal carcinomas, ductal carcinoma in situ dcis, and adenocarcinoma. Basal and squamous cell skin cancer early detection, diagnosis, and staging cancer. The concept of a disease continuum with varying degrees of squamous metaplasia was supported by stevenson et al. Almost half of patients are misdiagnosed as squamous. Desmoplastic trichoepithelioma the term desmoplastic trichoepithelioma was introduced in 1977 by brownstein and shapiro in a series of 50 cases. Cutaneous squamous cell carcinoma scc exhibiting microcystic adnexal carcinomalike.
Histopathology images of invasive ductal carcinoma, nos by. Squamoid eccrine ductal carcinoma should be considered in the differential diagnosis of cutaneous adnexal neoplasms showing squamoid and ductal features of differentiation. Some early cancers may have signs and symptoms that can be noticed, but that is not always the case. Sedc is exceedingly rare, and only a few cases have been reported. It is a rare tumour and making a histopathological diagnosis is difficult. The designation of sedc should likely encompass both the divergent biphasic neoplasms that have been previously reported in the literature, but also include a well differentiation eccrine carcinoma in which there is an intrinsic squamous component within a tumor exhibiting classic features of eccrine ductal carcinoma. Clear cell changes are a prominent feature in a wide variety of squamous and adnexal carcinomas. This study describes the clinical and pathological findings in a series of 21 cases of epc showing extensive squamous differentiation. Its tumor cells are characterized by a squamous appearance, similar to the one observed in epidermal cells. High power microscopic image showing atypical squamous epithelium.
One month prior to excision, the size of the lesion decreased from. Our patient was a 79yearold male, presenting to our hospital with the complaint of a longterm persistent wound in the scalp. It is frequently found on the lower extremities, and it equally affects both sexes in the sixth and seventh decade. A wideningmargins surgery and grafting were performed, which again resulted in positive margins. Eccrine carcinoma is a rare tumour that typically presents as a slow growing plaques or nodules on the scalp but can arise at other sites. Histopathologic features of sedc show the atypical squamous cell infiltration. An asymptomatic erythematous surface lesion of the soft palate, tonsillar pillar, lateral and ventral tongue and floor of the mouth is the most common presentation of carcinoma in situ and early squamous cell carcinoma. At least with the designation of eccrine ductal carcinoma with squamous differentiation, we would suggest that the 2 terms likely refer to a similar spectrum of carcinomas with a common histogenesis. Squamoid eccrine ductal carcinoma sedc is an extremely rare cutaneous tumor of unknown etiology. Pure primary squamous cell carcinoma of the breast is a rare condition and is considered to arise through metaplastic change of ductal carcinoma cells. Primary squamous cell thyroid carcinoma shows an aggressive biological phenotype resulting in poor prognosis for patients. Squamoid eccrine ductal carcinoma is an eccrine carcinoma subtype, and only twelve cases have been reported until now. This group includes eccrine ductal carcinoma, basaloid eccrine carcinoma, clear cell eccrine carcinoma and other nonspecified sweat gland carcinomas. The second conspicuous group of neoplasms of our series cases 4552 was characterized by prominent tubular structures, as an expression of tumor differentiation toward the dermal portion of the sweat duct.
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